The Dan L. Duncan Cancer Center is seeking proposals that will increase collaborative
translational research. Proposals will require at least two investigators and have
clear translational endpoints. Investigators should be from different programs,
or if within a program, from different labs or thematic areas. Consideration will
be given to proposals that have a good potential to develop into externally funded
collaborative grants. This year there is a particular interest in funding projects
with translational partners in the Viral and Molecular Oncogenesis and the Cancer
Prevention and Population Sciences Programs, though that is not required. Translational
collaborations with colleagues in other TMC institutions will be considered if the
partner can contribute matching funds from their home institution. No subcontracts
will be allowed.
Up to four (4) one year grants of up to $100,000 will be awarded. Funds can be split
into more than one account by PI, but unified progress reports based on the projects
aims will be required with both PI's collaborators input. No indirect costs will
be required. Funds not expended within two years of the project award will be returned
to the DLDCC to fund future pilot projects.
We encourage you to consult with your program leaders.
Format of the Application
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Applications should be submitted online at
This application is a modified version of the PHS 398 application. Please read and
follow the instructions carefully. The application must be single-sided and single
spaced, staying within the margin limitations (at least 1/2”). The font must be
Arial typeface and a font size of 11 points or larger.
Please submit the application in the following order:
- SUMMARY SHEET - This page is part of the online application.
- PROJECT DESCRIPTION
Project description template
State the application’s broad, long-term objectives and specific aims, making reference
to the health relatedness of the project. Describe concisely the research design
and methods for achieving these goals. Avoid summaries of past accomplishments and
the use of the first person. This description is meant to serve as a succinct and
accurate description of the proposed work when separated from the application. DO NOT EXCEED ONE PAGE FOR PROJECT DESCRIPTION.
RESEARCH PLAN (maximum 6 pages)
The research plan should include sufficient information needed for evaluation of
the project, independent of any other document. Be specific and informative, and
All applications must include an Introduction.
Organize Items a-d, to answer these questions:
- What do you intend to do?
- Why is the work important?
- What has already been done?
- How are you going to do the work?
- Specific Aims - State concisely the goals of the proposed
research and summarize the expected outcome(s), including the impact that the results
of the proposed research will exert on the research field(s) involved.
List succinctly the specific objectives of the research proposed, e.g., to test
a stated hypothesis, create a novel design, solve a specific problem, challenge
an existing paradigm or clinical practice, address a critical barrier to progress
in the field, or develop new technology.
- Significance - Explain the importance of the problem or
critical barrier to progress in the field that the proposed project addresses.
Explain how the proposed project will improve scientific knowledge, technical capability,
and/or clinical practice in one or more broad fields.
Describe how the concepts, methods, technologies, treatments, services, or preventative
interventions that drive this field will be changed if the proposed aims are achieved.
- Innovation - Explain how the application challenges and
seeks to shift current research or clinical practice paradigms.
Describe any novel theoretical concepts, approaches or methodologies, instrumentation
or intervention(s) to be developed or used, and any advantage over existing methodologies,
instrumentation or intervention(s).
Explain any refinements, improvements, or new applications of theoretical concepts,
approaches or methodologies, instrumentation or interventions.
- Approach - Describe the overall strategy, methodology,
and analyses to be used to accomplish the specific aims of the project. Unless addressed
separately in Item 5.5.15, include how the data will be collected, analyzed, and
interpreted as well as any resource sharing plans as appropriate.
Discuss potential problems, alternative strategies, and benchmarks for success anticipated
to achieve the aims.
If the project is in the early stages of development, describe any strategy to establish
feasibility, and address the management of any high risk aspects of the proposed
Point out any procedures, situations, or materials that may be hazardous to personnel
and precautions to be exercised.
- Bibliography and References Cited - Provide a bibliography
of any references cited in the Research Plan. Each reference must include names
of all authors (in the same sequence in which they appear in the publication), the
article and journal title, book title, volume number, page numbers, and year of
publication. Include only bibliographic citations. Follow scholarly practices in
providing citations for source materials relied upon in preparing any section of
The references should be limited to relevant and current literature. While there
is not a page limitation, it is important to be concise and to select only those
literature references pertinent to the proposed research. (References
are not included in six page limit)
Provide a detailed budget with complete justification for each item. Funds are to
be used primarily for supplies and technical support. P.I. salary and major equipment
are not allowed. Proposals cannot exceed $100,000 in total costs. No indirect costs
will be required.
- BIOGRAPHICAL SKETCH (maximum four pages)
Biosketch MS Word format.
Provide a biographical sketch of the principal investigator and collaborator(s),
including the following information:
- Personal statement. Briefly describe why your experience and qualifications make
you particularly well-suited for your role (e.g., PD/PI, mentor) in the project
that is the subject of the application.
- Positions and Honors. List in chronological order previous positions, concluding
with the present position. List any honors. Include present membership on any Federal
Government public advisory committee.
- Peer-reviewed publications or manuscripts in press. NIH encourages applicants to
limit the list of selected peer-reviewed publications or manuscripts in press to
no more than 15. Do not include manuscripts submitted or in preparation. The individual
may choose to include selected publications based on recency, importance to the
field, and/or relevance to the proposed research. When citing articles that fall
under the Public Access Policy, were authored or co-authored by the applicant and
arose from NIH support, provide the NIH Manuscript Submission reference number (e.g.,
NIHMS97531) or the PubMed Central (PMC) reference number (e.g., PMCID234567) for
each article. If the PMCID is not yet available because the Journal submits articles
directly to PMC on behalf of their authors, indicate "PMC Journal - In Process."
A list of these Journals is posted at:
http://publicaccess.nih.gov/submit_process_journals.htm. Citations that
are not covered by the Public Access Policy, but are publicly available in a free,
online format may include URLs or PMCID numbers along with the full reference (note
that copies of publicly available publications are not acceptable as appendix material.)
- Research Support. List both selected ongoing and completed research projects for
the past three years (Federal or non-Federally-supported). Begin with the projects
that are most relevant to the research proposed in the application. Briefly indicate
the overall goals of the projects and responsibilities of the key person identified
on the Biographical Sketch. Do not include number of person months or direct costs.
ASSURANCES AND COMPLIANCE
Neither pending nor approved protocols are required with this application. However,
if funded, researchers must obtain institutional approval for proposals involving
human subjects, animals, radioisotopes, or biohazardous materials.
Printable Format of Application